Innovación

En NUCAPS llevamos más de 5 años desarrollando y produciendo un nuevo tipo de ingredientes funcionales. A lo largo de todo este tiempo, y gracias a nuestro firme compromiso con la innovación, hemos logrado estar presentes en más de 21 países de todo el mundo, con 7 familias de patentes internacionales y cerca de 47 proyectos activos de I+D.

Patentes
internacionales

Proyectos
activos de I+D

Países
en el mundo

Estudios de toxicidad

Estudio Toxicidad Aguda Nanopartículas Zeína. CIFA 009/2012. Universidad de Navarra
Estudio Toxicidad Nanopartículas Zeína. CIFA 015/2012 – Universidad de Navarra
Estudio Toxicidad Aguda Nanopartículas Caseína. CIFA 003/2012 – Universidad de Navarra
Estudio Toxicidad Nanopartículas Caseína. CIFA 010/2012 – Universidad de Navarra

Publicaciones científicas

Zein nanoparticles for oral folic acid delivery. Peñalva R, Esparza I, González-Navarro CJ, Quincoces G, Peñuelas I, Irache JM.. J Drug Deliv Sci Technol. 2015;30:450–7.
Zein-Based Nanoparticles Improve the Oral Bioavailability of Resveratrol and Its Anti-inflammatory Effects in a Mouse Model of Endotoxic. Penalva R, Esparza I, Larraneta E, González-Navarro CJ, Gamazo C, Irache JM. Shock. J Agric Food Chem. 2015;63(23):5603–11.
Casein nanoparticles as carriers for the oral delivery of folic acid. Penalva R, Esparza I, Agüeros M, Gonzalez-Navarro CJ, Gonzalez-Ferrero C, Irache JM. Food Hydrocoll. 2015;44:399–406.
Zein nanoparticles for oral delivery of quercetin: Pharmacokinetic studies and preventive anti-inflammatory effects in a mouse model of endotoxemia Penalva R, González-Navarro CJ, Gamazo C, Esparza I, Irache JM.. Nanomedicine. 2017 Jan;13(1):103–10.
Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease. Moreno LCG e. I, Puerta E, Suárez-Santiago JE, Santos-Magalhães NS, Ramirez MJ, Irache JM. Int J Pharm. 2017;517(1–2):50–7.
Optimization and evaluation of zein nanoparticles to improve the oral delivery of glibenclamide. In vivo study using C. elegans. D. Lucio, M.C. Martínez-Ohárriz, G. Jaras, P. Aranaz, C.J. González-Navarro, A. Radulescu, J.M. Irache, , Eur. J. Pharm. Biopharm. 121 (2017) 104–112.
Thermal protection of b-carotene in re-assembled casein micelles during different processing technologies applied in food industry. María-José Sáiz-Abajo, Carolina González-Ferrero, Ana Moreno-Ruiz, Ana Romo-Hualde, Carlos J. González-Navarro. 2013. Food Chemistry.
Toxicity and biodistribution of orally administered casein nanoparticles Gil AG, Irache JM, Peñuelas I, González Navarro CJ, López de Cerain A.. Food Chem Toxicol. 2017;106:477–86.
Soybean protein-based microparticles for oral delivery of probiotics with improved stability during storage and gut resistance. González-Ferrero C, Irache JM, González-Navarro CJ.. Food Chem. 2018;239:879–88.
Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles. Peñalva R, Morales J, González-Navarro C, Larrañeta E, Quincoces G, Peñuelas I, et al.. Int J Mol Sci. 2018;19(9):2816.
Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer‐Membrane Vesicles Incorporated into Zein‐Based Nanoparticles. Jose Matías, Ana Brotons, Santiago Cenoz, Isidoro Pérez, Muthanna Abdulkarim, Mark Gumbleton, Juan M. Irache, Carlos Gamazo. Vaccines 2020.
Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate Inchaurraga L, Martínez-López AL, Abdulkarim M, Gumbleton M, Quincoces G, Peñuelas I, et al.. Int J Pharm X [Internet]. 2019;1(January):100006.
Casein nanoparticles in combination with 2-hydroxypropyl-β-cyclodextrin improves the oral bioavailability of quercetin. Rebeca Peñalva, Irene Esparza, Jorge Morales-Gracia, Carlos J. González-Navarro, Eneko Larrañeta, Juan M. Irache. International Journal of Pharmaceutics. 2019.
Zein nanoparticles improve the oral bioavailability of resveratrol in humans. Brotons-Canto A, Gonzalez-Navarro CJ, Gurrea J, González-Ferrero C, Irache JM. Drug Deliv Sci Technol. 2020;57(January):101704.
Zein-based nanoparticles for the oral delivery of insulin. Laura Inchaurraga, Ana L. Martínez-López, Nekane Martin-Arbella, Juan M. Irache. Drug Delivery and Translational Research.
Encapsulation of Probiotics in Soybean Protein-Based Microparticles Preserves Viable Cell Concentration in Foods All Along the Production and Storage Processes. C. González-Ferrero, J.M. Irache, B. Marín-Calvo , L. Ortiz-Romero, R. Virto-Resano, C. J. González-Navarro.. J Microencapsul 37 (2020) 242-253.
Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats. Ana Brotons-Canto; Carlos J. González-Navarro; Ana Gloria Gil; Eduardo Asin-Prieto; María José Saiz; Josep Manuel Llabrés. Pharmaceutics 2021, Volume 13, Issue 3, 361.
Oral administration of zein-based nanoparticles reduces glycemia and improves glucose tolerance in rats. Cristian Reboredo, Carlos J.González-Navarro, Ana L.Martínez-López, Juan M.Irache. International Journal of Pharmaceutics. Volume 628, 25 November 2022.
Encapsulation of Lactobacillus plantarum in casein-chitosan microparticles facilitates the arrival to the colon and develops an immunomodulatory effect. Rebeca Peñalva, Ana Luisa Martínez-López, Carlos Gamazo, Carlos J.Gonzalez-Navarro, Carolina González-Ferrero, Raquel Virto-Resano, Ana Brotons-Canto, Ana Isabel Vitas, Maria Collantes, Ivan Peñuelas, Juan M.Irache. Food Hydrocolloids. Volume 136, Part A, March 2023, 108213.
Encapsulated Phytomedicines against Cancer: Overcoming the “Valley of Death. Ana Brotons-Canto, Claudia P. Urueña, Izaskun Imbuluzqueta, Edurne Luque-Michel, Ana Luisa Martinez-López, Ricardo Ballesteros-Ramírez, Laura Rojas and Susana Fiorentino. Pharmaceutics 2023, 15(4), 1038; Special Issue «The Study of Plant Compounds in Antioxidant Activity and Anticancer Activity».
3D printing of microencapsulated Lactobacillus rhamnosus for oral delivery. Pablo Rosas-Val, Masoud Adhami, Ana Brotons-Canto, Carlos Gamazo, Juan M. Irache, Eneko Larrañeta. International Journal of Pharmaceutics. Volume 641, 25 June 2023, 123058.
Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin. Raquel Campion, Carlos J. Gonzalez-Navarro, Ana Luisa Martínez Lopez, M. Cristina Martínez, María-Jose Saiz, Maria Collantes, Ivan Peñuelas, Juan M. Irache. International Journal of Pharmaceutics. Volume 643, 25 August 2023, 123216

Innovación

Patentes internacionales

Proyectos activos de I+D

Países en el mundo

Estudios de toxicidad

Publicaciones científicas

Patentes
internacionales

Proyectos
activos de I+D

Países
en el mundo